Lin Shyr-Yi Ph.D

近年計畫

107 臺北醫學大學自有貴重儀器共用服務計畫

107 anti-EGFR x anti-FAP雙辨識特異性抗體結合包覆抗癌藥物Irinotecan標靶微脂體治療胰臟癌之研究(1/3)

106 臺北醫學大學自有貴重儀器共用服務計畫

106 PLA Subdermal注射劑改善諮詢

106 動物用藥品風險評估及其趨勢之探討

106 開發可注射型溫敏水膠體-建置原位成型緩釋長效型抗體藥物水膠體輸送技術平台計畫-先期研究

106 開發緩釋型明膠微粒膠體劑型之研究勞務採購

105 臺北醫學大學自有貴重儀器共用服務計畫

105 106年度「推動中醫藥用藥安全衛生教育及成效評估探討」

105 106年度委託科技研究計畫-「動物用藥品風險管理評估」

105 粉末狀明膠微粒體佐劑之開發

104 Nilotinib胃滯留劑型之體外溶離暨體內藥動學研究

104 105年度「強化中藥用藥安全衛生教育模式」

論文 Journal Paper

• 2018 Wu GC,Lin SY,Liang HJ,Hou WC. 135-Day Interventions of Yam Dioscorin and the Dipeptide Asn-Trp (NW) To Reduce Weight Gains and Improve Impaired Glucose Tolerances in High-Fat Diet-Induced C57BL/6 Mice . J. Agric. Food Chem .2018 ;(66):645-652
• 2018 Su CY,Chen M,Chen LC,Ho YS,Ho HO,Lin SY,Chuang KH, Sheu MT. Bispecific antibodies (anti-mPEG/anti-HER2) for active tumor targeting of docetaxel (DTX)-loaded mPEGylated nanocarriers to enhance the chemotherapeutic efficacy of HER2-overexpressing tumors . Drug Delivery .2018 ;(25):1066-1079
• 2018 Suk FM,Chang CC,Lin RJ,Lin SY,Chen YT,Liang YC. MCPIP3 as a potential metastasis suppressor gene in human colorectal cancer . International J of Molecular Sciences .2018 ;(19):1350-1362
• 2018 Suk FM,Chang CC,Lin RJ,Lin SY,Liu SC,Jau CF, Liang YC. ZFP36L1 and ZFP36L2 inhibit cell proliferation in a cyclin D-dependent and p53-independent manner . Sci Rep .2018 ;(8):2742-2755
• 2018 Lin SF,Jiang PL ,Tsai JS,Huang YY,Lin SY,Lin JH, Liu DZ. Surface assembly of poly(I:C) on polyethyleneimine-modified gelatin nanoparticles as immunostimulatory carriers for mucosal antigen delivery. . J Biomed Mater Res B Part B .2018
• 2017 Chang WH,Niu DM,Lu CY,Lin SY,Liu TC,Chang JG. Modulation the alternative splicing of GLA (IVS4+919G>A) in Fabry disease . PLOS ONE .2017 ;(12):1-17
• 2017 Chang CC,Chang YS,Wang SH,Lin SY,Chen YH,Chen JH. Primary Sjogren’s syndrome and the risk of acute pancreatitis: a nationwide cohort study . BMJ Open .2017 ;(11):e01480-e01480
• 2017 Lu YL,Lin SY,Fang SU,Hsieh YY,Chen CR,Wen C, Chang CI, Hou WC. Hot-Water Extracts from Roots of Vitis thunbergii var. taiwaniana and Identified ε-Viniferin Improve Obesity in High-Fat Diet-Induced Mice . Journal of Agricultural and Food Chemistry .2017 ;(65):2521-2529
• 2016 Liu YH,Lin YS,Huang YW,Fang SU,Lin SY,Hou WC. Protective Effects of Minor Components of Curcuminoids on Hydrogen Peroxide-Treated Human HaCaT Keratinocytes . Journal of Agricultural and Food Chemistry .2016 ;(64):3598-3608
• 2016 Lin YS,Han CH,Lin SY,Hou WC. Synthesized peptides from yam dioscorin hydrolysis in silico exhibit dipeptidyl peptidase-IV inhibitory activities and oral glucose tolerance improvements in normal mice . Journal of Agricultural and Food Chemistry .2016 ;(64):6451-6458
• 2015 Lin YS,Wu WC,Lin SY,Hou WC. GlycineHydroxamate Inhibits TyrosinaseActivity and Melanin Contents through downregulatingcAMP/PKA Signaling Pathways . Amino Acids .2015 ;(47):617-625
• 2015 Chang CC,Tsai YH,Liu Y,Lin SY,Liang YC. Calcium-containing crystals enhance RANKL/M-CSF-mediated osteoclastogenesis via ERK and p38 pathways . Rheumatology .2015 ;(54):1913-1922
• 2015 Shih SL,Lin YS,Lin SY,Hou WC. Effects of yam dioscorin interventions on improvements of the metabolic syndrome in high-fat diet-induced obese rats . Botanical Studies .2015 ;(56):1-9
• 2015 Cheng TC,Tu SH,Chen LC,Chen MY,Chen WY,Lin YK, Ho CT, Lin SY, Wu CH, Ho YS. Down-regulation of α-L-fucosidase 1 expression confers inferior survival for triple-negative breast cancer patients by modulating the glycosylation status of the tumor cell surface . Oncotarget .2015 ;(6):21283-21300
• 2015 Simon-Lorier E,Lin RJ,Kalayanaro SM,Chuansumrit A,Casademont I,Lin SY, Yu HP, Lert-itthiporn W, Chaiyaratana W, Tangthawornchaikul N, Tangararatchakit K,. High anti-dengue viral activity of OAS gene family is associated with increased severity . J of infectious disease .2015 ;(accept):accept-accept
• 2015 Suk FM,Lin SY,Lin RJ,Hsine YH,Liao YJ,Fang SU, Liang YC. Bortezomib inhibits Burkitt’s lymphoma cell proliferation by downregulating sumoylated hnRNP K and c-Myc expression . Oncotarget .2015 ;(6):25988-26001
• 2015 Huang YW,Wang TC,Yang SS,Lin SY,Fu SC,Hu JT, Liu CJ, Kao JH, Chen DS. Increased risk of hepatocellular carcinoma in chronic hepatitis C patients with new onset diabetes: A nationwide cohort study . Alimentary Pharmacology & Therapeutics .2015 ;(accept):accept-accept
• 2015 Liu YH,Lin YS,Lin KL,Lu YL,Chen CH,Chien MY, Shang HF, Lin SY, Hou WC. Effects of hot-water extracts from Ganoderma lucidum residues and solid-state fermentatio nresidues on prebiotic and immune-stimulatory activities in vitro and the powdered residues used as broiler feed additives in vivo . Botanical Studies .2015 ;(56):1-10
• 2015 Lee YJ,Chen JZ,Lin HC,Liu HY,Lin SY,Lin HH, Fang CH, Hsueh PR. Impact of active screening for methicillin-resistant Staphylococcus aureus (MRSA) and decolonization on MRSA infections, mortality, and medical cost: a quasi-experimental study in surgical intensive care unit. . Crit Care .2015 ;(8):143-153
• 2015 Chang CC,Chen LY,Yang KH,Chen QY,Liang YC,Lin SY, Liu YC. Surface-enhanced Raman scattering on a silver film-modified Au nanoparticle-decorated SiO2 mask array . RSC Advances .2015 ;(5):66096-66103
• 2015 Lin SY,Huang GC,Hsieh YY,Lin YS,Han CH,Wen CL, Chang CI, Hou WC. Vitis thunbergii var. taiwaniana Extracts and Purified Compounds Ameliorate Obesity in High-Fat Diet-Induced Obese Mice . J. Agric. Food Chem .2015 ;(63):9286-9294
• 2014 Han CH,Lin YF,Lin YS,Lee TL,Huang WJ,Lin SY, Hou WC. Effects of yam tuber protein, dioscorin, on attenuating oxidative status and learning dysfunction in D-galactose-induced BALB/c mice . Food and Chemical Toxicology .2014 ;(65):356-363
• 2014 Lin RJ,Chu JS,Chien HL,Tseng CH,Ko PC,Mei YY, Tang WC, Kao YT, Cheng HY, Liang YC, Lin SY. MCPIP1 Suppresses Hepatitis C Virus Replication and Negatively Regulates Virus-induced Proinflammatory Cytokine Responses . The Journal of Immunology .2014 ;(193):4159-4168
• 2014 Liu LY,Huang WJ,Ho FM,Lin RJ,Lin SY,Suk FM, Liang YC. N-Hydroxycinnamide derivatives of osthole inhibit cell migration and invasion by suppressing Smad2 and Akt pathways in human colorectal adenocarcinoma cells. . Chem Biol Interact .2014 ;(217):1-8